Jefferson County John Doe may refer to:
Alabama
1980s
- Jefferson County John Doe (1981), who was found near a closed-down college in Birmingham, Alabama.
- Jefferson County John Doe (1987)
- Jefferson County John Doe (June 1988)
- Jefferson County John Doe (October 1988)
1990s
- Jefferson County John Doe (September 1993)
- Jefferson County John Doe (November 1997)
- Jefferson County John Doe (1999)
2000s
- Jefferson County John Doe (2002), who was found by a survey crew near a pathway in Birmingham, Alabama.
- Jefferson County John Doe (June 2004)
- Jefferson County John Doe (September 2004)
- Jefferson County John Doe (2006)
- Jefferson County John Doe (2007), who was found after an anonymous tip in Birmingham, Alabama.
2010s
- Jefferson County John Doe (February 2012)
- Jefferson County John Doe (December 2012)
- Jefferson County John Doe (2013)
- Jefferson County John Doe (2016)
- Jefferson County John Doe (2018)
- Jefferson County John Doe (May 2019)
2020s
- Jefferson County John Doe (March 2020)
- Jefferson County John Doe (July 5, 2020), who was found deceased on a porch in Birmingham, Alabama.
- Jefferson County John Doe (July 6, 2020)
Arkansas
- Jefferson County John Doe (1918), who was an American serviceman who died in the Great Flu Pandemic of 1918 in Pine Bluff, Arkansas.
Colorado
- Jefferson County John Doe (1966), who was an infant found deceased on a hillside in Lakewood, Colorado.
- Jefferson County John Doe (2000), who was found on the Galbraith Hiking Trail near Golden, Colorado.
Kentucky
1990s
- Jefferson County John Doe (April 1997), who was found in the Ohio River in Louisville, Kentucky.
- Jefferson County John Doe (August 7, 1998), who was found floating in the Ohio River near McAlpin Locks in Louisville, Kentucky.
2000s
- Jose (2004), who was found in Louisville, Kentucky.
- Jefferson County John Doe (2009), who murdered in Louisville, Kentucky. His killers have been arrested.
2020s
New York
- Jefferson County John Doe (1908), who found to have washed ashore in Rays Cove, Henderson Bay, New York in 1908.
Pennsylvania
- Jefferson County John Doe (July 1986), who was found strangled to death in Washington Township, Pennsylvania.
Tennessee
- Jefferson County John Doe (2019), who was found murdered in Dandridge, Tennessee. His case is undergoing testing by the DNA Doe Project.
Texas
- Jefferson County John Doe (1973), who was a teenage boy or young man who was found in Jefferson County, Texas. He was a victim of the Houston Mass Murders.
- Jefferson County John Doe (1993), who was found deceased along Highway 73 in Port Arthur, Texas.
West Virginia
- Jefferson County John Doe (August 1986), who was found shot to death in Kearneysville, West Virginia.